Let Our Cryo-EM
Experts Guide You

We are a US based CRO with in-house microscopes, offering protein production and cryo-EM services to support both structure-based drug design and nanoparticle characterization.

Explore The NIS Difference

Experts

Accessibility

Technology

Harness the Power of Cryo-EM with our Core Services

3D protein structure reconstruction of hERG protein from cryo-EM imaging and analysis | structural biology | Nano Imaging Services

Scientific rendering of Liposome from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services

High resolution 3D model of trimer determined by cryo-EM imaging and analysis | structural biology | Nano Imaging Services

3D reconstruction of Human papillomavirus (HPV) virus like particle (VLP) from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services

Structural Biology

Protein Production

Nanoparticle Characterization

Method Validation

Publications

NIS's cryo-EM services in action

Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity

August 1, 2025

Read about novel Sec61 inhibitor structures solved with cryo-EM in a recent publication from Kezar Life Sciences, the University of Helsinki, UCB, and the University of California, San Francisco.

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Characterization of VSV-GP morphology by cryo-EM imaging and SEC-MALS

February 6, 2025

See how cryo-TEM can provide comprehesive characterization of vesicular stomatitis virus (VSV) expressing the glycoprotein of the lymphocytic choriomeningitis virus in a recent publication from Boehringer Ingelheim Pharmaceuticals.

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Structure of anellovirus-like particles reveal a mechanism for immune evasion

August 22, 2024

Anelloviruses are the principal constituent of the commensal human virome. However, their structure and features were not well studied and remain elusive.

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Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

August 16, 2024

Read the latest research collaboration between Calico Life Sciences, AbbVie, C4 Therapeutics, and NIS, solving phosphatase structures supported by cryo-EM data collection.

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Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization

August 6, 2024

This research focused on developing a peptoid-based nanoparticle platform, termed "Nutshells", for the delivery of therapeutic mRNA.

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High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy

April 20, 2024

Structural analysis of membrane proteins is often challenging due to low protein yields and their unstable nature. HiTehA is particularly challenging due to its encapsulation in detergent micelles, which obstructs proper alignment of projections needed for 3D structure reconstruction.

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