Morphology & Particle Shape Analysis

Qualitative Morphology Assessment with Cryo-TEM

Cryo-TEM provides per-particle insights into morphological characteristics of nanoparticles:

Particle shape & circularity
Quantitative particle classification, including multivesicular or multicompartmental particles
Irregular particles & unexpected results
Integrity, impurities
Level of aggregation
Formulation uniformity

Detailed Insights into Nanoparticle Morphology

Cryo-TEM images & quantitative analysis provides answers about a wide variety of morphological characteristics, in one study.

Morphology analysis is essential for optimizing formulation, ensuring safety and efficacy, and meeting regulatory standards.

‍

Meet With Us

Samples We Can Perform Morphology Analysis On

microscopic black and white image of adeno-associated virus (AAV) characterization with cryo-TEM

Adeno-Associated Virus (AAV)
Adeno-Associated Virus (AAV)

microscopic black and white image cryo-TEM imaging of adenovirus | nanoparticle characterization

Adenovirus
Adenovirus

Bacteriophage
Bacteriophage

Extracellular Vesicles & Exosomes
Extracellular Vesicles & Exosomes

Gold Nanoparticles
Gold Nanoparticles

microscopic black and white image of Human Papillomavirus (HPV) Characterization by cryo-TEM | nanoimaging services NIS

Human Papillomavirus (HPV)
Human Papillomavirus (HPV)

Iron Nanoparticle characterization by Cryo-TEM | nanoparticle characterization | nanoimaging services

Iron Nanoparticles
Iron Nanoparticles

microscopic black and white image of lentivirus characterization services with cryo-TEM | nanoimaging services

Lentivirus
Lentivirus

black and white microscopic image of of lipid nanoparticle nanoparticle LNP characterization | nanoimaging services

Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads

black and white microscopic image of doxorubicin encapsulated liposome nanoparticle characterization by cryo-TEM

Liposomes
Liposomes

Micelles
Micelles

Other Nanoparticle Samples
Other Nanoparticle Samples

Polymeric Nanoparticles
Polymeric Nanoparticles

Protein Based Nanoparticles
Protein Based Nanoparticles

Two Component Systems
Two Component Systems

Vesicular Stomatitis Virus
Vesicular Stomatitis Virus

Services Related To Morphology Analysis

Complete Morphology Assessment with Cryo-TEM

Direct determination of particle morphology is a critical aspect of nanoparticle characterization. Typical analyses include particle size distribution, shape, and overall appearance of particles in a sample, and can include quantitative analysis of circularity.

All of these measurements can be obtained in one cryo-TEM or negative stain imaging study, with a small amount of sample.

Meet with Us